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1 Stone, J. C., Atkinson, T., Smith, M. & Pawson, T. Identification of functional regions in the transforming protein of Fujinami sarcoma virus by in-phase insertion mutagenesis. Cell 37, 549-558 (1984).
2 Sadowski, I., Stone, J. C. & Pawson, T. A noncatalytic domain conserved among cytoplasmic protein-tyrosine kinases modifies the kinase function and transforming activity of Fujinami sarcoma virus P130gag-fps. Molecular and cellular biology 6, 4396-4408 (1986).
3 Moran, M. F. et al. Src homology region 2 domains direct protein-protein interactions in signal transduction. Proceedings of the National Academy of Sciences 87, 8622-8626 (1990).
4 Anderson, D. et al. Binding of SH2 domains of phospholipase C gamma 1, GAP, and Src to activated growth factor receptors. Science 250, 979-982 (1990).
5 Isaacs, A. & Lindenmann, J. Virus interference. I. The interferon. Proceedings of the Royal Society of London. Series B-Biological Sciences 147, 258-267 (1957).
6 Baron, S. et al. The interferons: mechanisms of action and clinical applications. Jama 266, 1375-1383 (1991).
7 Zinn, K., Dimaio, D. & Maniatis, T. Identification of two distinct regulatory regions adjacent to the human β-interferon gene. Cell 34, 865-879 (1983).
8 Miyamoto, M. et al. Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-β gene regulatory elements. Cell 54, 903-913 (1988).
9 Fujita, T. et al. Evidence for a nuclear factor (s), IRF‐1, mediating induction and silencing properties to human IFN‐beta gene regulatory elements. The EMBO journal 7, 3397-3405 (1988).
10 Derman, E. et al. Transcriptional control in the production of liver-specific mRNAs. Cell 23, 731-739 (1981).
11 Clayton, D. F. & Darnell, J. Changes in liver-specific compared to common gene transcription during primary culture of mouse hepatocytes. Molecular and cellular biology 3, 1552-1561 (1983).
12 Clayton, D. F., Harrelson, A. L. & Darnell, J. Dependence of liver-specific transcription on tissue organization. Molecular and cellular biology 5, 2623-2632 (1985).
13 Larner, A. et al. Transcriptional induction of two genes in human cells by beta interferon. Proceedings of the National Academy of Sciences 81, 6733-6737 (1984).
14 Friedman, R. L., Manly, S. P., McMahon, M., Kerr, I. M. & Stark, G. R. Transcriptional and posttranscriptional regulation of interferon-induced gene expression in human cells. Cell 38, 745-755 (1984).
15 Kerr, I. M., Brown, R. E. & Hovanessian, A. G. Nature of inhibitor of cell-free protein synthesis formed in response to interferon and double-stranded RNA. Nature 268, 540-542 (1977).
16 Aguet, M. High-affinity binding of 125 I-labelled mouse interferon to a specific cell surface receptor. Nature 284, 459-461 (1980).
17 Aguet, M., Dembi?, Z. & Merlin, G. Molecular cloning and expression of the human interferon-γ receptor. Cell 55, 273-280 (1988).
18 Levy, D., Larner, A., Chaudhuri, A., Babiss, L. & Darnell, J. Interferon-stimulated transcription: isolation of an inducible gene and identification of its regulatory region. Proceedings of the National Academy of Sciences 83, 8929-8933 (1986).
19 Kessler, D., Pine, R., Pfeffer, L., Levy, D. & Darnell Jr, J. Cells resistant to interferon are defective in activation of a promoter‐binding factor. The EMBO journal 7, 3779-3783 (1988).
20 Levy, D. E., Kessler, D. S., Pine, R., Reich, N. & Darnell, J. Interferon-induced nuclear factors that bind a shared promoter element correlate with positive and negative transcriptional control. Genes & development 2, 383-393 (1988).
21 Friedman, R. L. & Stark, G. R. α-Interferon-induced transcription of HLA and metallothionein genes containing homologous upstream sequences. Nature 314, 637-639 (1985).
22 Porter, A. et al. Interferon response element of the human gene 6‐16. The EMBO journal 7, 85-92 (1988).
23 Dale, T. C., Imam, A., Kerr, I. M. & Stark, G. R. Rapid activation by interferon alpha of a latent DNA-binding protein present in the cytoplasm of untreated cells. Proceedings of the National Academy of Sciences 86, 1203-1207 (1989).
24 Fu, X., Colgan, J. & Manley, J. Multiple cis-acting sequence elements are required for efficient splicing of simian virus 40 small-t antigen pre-mRNA. Molecular and cellular biology 8, 3582-3590 (1988).
25 Fu, X.-Y., Ge, H. & Manley, J. L. The role of the polypyrimidine stretch at the SV40 early pre‐mRNA 3′ splice site in alternative splicing. The EMBO journal 7, 809-817 (1988).
26 Fu, X. & Manley, J. L. Factors influencing alternative splice site utilization in vivo. Molecular and cellular biology 7, 738-748 (1987).
27 Fu, X.-Y., Kessler, D. S., Veals, S. A., Levy, D. E. & Darnell, J. ISGF3, the transcriptional activator induced by interferon alpha, consists of multiple interacting polypeptide chains. Proceedings of the National Academy of Sciences 87, 8555-8559 (1990).
28 Fu, X.-Y., Schindler, C., Improta, T., Aebersold, R. & Darnell, J. E. The proteins of ISGF-3, the interferon alpha-induced transcriptional activator, define a gene family involved in signal transduction. Proceedings of the National Academy of Sciences 89, 7840-7843 (1992).
29 Schindler, C., Fu, X.-Y., Improta, T., Aebersold, R. & Darnell, J. E. Proteins of transcription factor ISGF-3: one gene encodes the 91-and 84-kDa ISGF-3 proteins that are activated by interferon alpha. Proceedings of the National Academy of Sciences 89, 7836-7839 (1992).
30 Fu, X.-Y. A transcription factor with SH2 and SH3 domains is directly activated by an interferon α-induced cytoplasmic protein tyrosine kinase (s). Cell 70, 323-335 (1992).
31 Schindler, C., Shuai, K., Prezioso, V. R. & Darnell, J. E. Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor. Science 257, 809-813 (1992).
32 Pellegrini, S., John, J., Shearer, M., Kerr, I. M. & Stark, G. R. Use of a selectable marker regulated by alpha interferon to obtain mutations in the signaling pathway. Mol Cell Biol 9, 4605-4612, doi:10.1128/mcb.9.11.4605 (1989).
33 Wilks, A. F. Two putative protein-tyrosine kinases identified by application of the polymerase chain reaction. Proc Natl Acad Sci U S A 86, 1603-1607, doi:10.1073/pnas.86.5.1603 (1989).
34 Wilks, A. F. et al. Two novel protein-tyrosine kinases, each with a second phosphotransferase-related catalytic domain, define a new class of protein kinase. Mol Cell Biol 11, 2057-2065, doi:10.1128/mcb.11.4.2057 (1991).
35 Velazquez, L., Fellous, M., Stark, G. R. & Pellegrini, S. A protein tyrosine kinase in the interferon αβ signaling pathway. Cell 70, 313-322 (1992).
36 Darnell, J. E., Kerr, I. M. & Stark, G. R. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264, 1415-1421 (1994).
37 Zhong, Z., Wen, Z. & Darnell, J. E., Jr. Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6. Science 264, 95-98, doi:10.1126/science.8140422 (1994).
38 Akira, S. et al. Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway. Cell 77, 63-71 (1994).
39 LIu, X., Robinson, G. W., Gouilleux, F., Groner, B. & Hennighausen, L. Cloning and expression of Stat5 and an additional homologue (Stat5b) involved in prolactin signal transduction in mouse mammary tissue. Proceedings of the National Academy of Sciences 92, 8831-8835 (1995).
40 Schwartz, D. M. et al. JAK inhibition as a therapeutic strategy for immune and inflammatory diseases. Nat Rev Drug Discov 16, 843-862, doi:10.1038/nrd.2017.201 (2017).
41 Taylor, P. C. et al. Baricitinib versus Placebo or Adalimumab in Rheumatoid Arthritis. N Engl J Med 376, 652-662, doi:10.1056/NEJMoa1608345 (2017).
42 Kalil, A. C. et al. Baricitinib plus Remdesivir for Hospitalized Adults with Covid-19. N Engl J Med, doi:10.1056/NEJMoa2031994 (2020).
43 Owen, K. L., Brockwell, N. K. & Parker, B. S. JAK-STAT Signaling: A Double-Edged Sword of Immune Regulation and Cancer Progression. Cancers (Basel) 11, doi:10.3390/cancers11122002 (2019).
44 Qureshy, Z., Johnson, D. E. & Grandis, J. R. Targeting the JAK/STAT pathway in solid tumors. J Cancer Metastasis Treat 6 (2020).
45 Nagano, T. Pouvoir immunisant du virus vaccinal inactivé par des rayons ultraviolets. Compt Rend Soc Biol 148, 1700-1702 (1954).
46 Blomstrom, D. C., Fahey, D., Kutny, R., Korant, B. D. & Knight Jr, E. Molecular characterization of the interferon-induced 15-kDa protein. Molecular cloning and nucleotide and amino acid sequence. Journal of Biological Chemistry 261, 8811-8816 (1986).
47 Reich, N. et al. Interferon-induced transcription of a gene encoding a 15-kDa protein depends on an upstream enhancer element. Proceedings of the National Academy of Sciences 84, 6394-6398 (1987).
48 Pine, R., Decker, T., Kessler, D., Levy, D. & Darnell, J. Purification and cloning of interferon-stimulated gene factor 2 (ISGF2): ISGF2 (IRF-1) can bind to the promoters of both beta interferon-and interferon-stimulated genes but is not a primary transcriptional activator of either. Molecular and Cellular Biology 10, 2448-2457 (1990).
49 Ge, H. & Manley, J. L. A protein factor, ASF, controls cell-specific alternative splicing of SV40 early pre-mRNA in vitro. Cell 62, 25-34 (1990).
50 Fu, X.-D. & Maniatis, T. Factor required for mammalian spliceosome assembly is localized to discrete regions in the nucleus. Nature 343, 437-441 (1990).
